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Medroxyprogesterone: General information

Depo provera Medroxyprogesterone is a derivative of progesterone and has no androgenic and estrogenic activity. In appropriate doses, the drug inhibits the secretion of gonadotropins (especially LH) and prevents ovulation.

Depo Medroxyprogesterone also reduces the severity of vasomotor symptoms in postmenopausal period.

The drug is metabolized in the liver.

The half-life is about 30 hours. The main metabolite is excreted by the kidneys.

Medroxyprogesterone: Indications

Dysfunctional (anovulatory) uterine bleeding;


correction of side effects from endometrial side during estrogen therapy in menopause;

differential diagnosis of primary and secondary amenorrhea.


Hypersensitivity to medroxyprogesterone.

Medroxyprogesterone: Precautions

Before using depo Medroxyprogesterone the physician should exclude that the patient might have tumor of genitals or mammary glands (except for cases of anti-tumor therapy).

The patients who have undergone a therapy against depression need careful monitoring in the treatment period.

Any patient who has the signs and / or symptoms consistent to embolic processes before continuing the therapy Medroxyprogesterone must re-evaluate the situation.

Some patients receiving low doses of Medroxyprogesterone might have decreased tolerance to glucose. This must be taken this into account when prescribing medication to diabetics.

Deciding to use depo Medroxyprogesterone during pregnancy is not recommended.

If during treatment with the drug, the patient undergoes cytological or histological examination of endometrial or cervical cancer, it is necessary to warn histologist about the therapy.

Medroxyprogesterone can affect the results of the following laboratory tests: determination of levels of gonadotropins, the definition plasma levels of progesterone, cortisol, estrogen, determine the level of pregnanediol in urine, conducting the test with a load of sugar ( glucose tolerance test ),etc.

The patient should inform the doctor before use medroxyprogesterone:

about past or existing liver disease, including jaundice;

of breast tumors, uterine or ovarian cancer;

of a pregnancy and the possible presence of pregnancy.

Tell your doctor if you have ever seen:




problems with the cardiovascular system;

kidney problems;



Medroxyprogesteron: Interactions

The patient should inform the doctor:

about whether he takes tablets Aminoglutethimide;

about all other drugs taken (including oral anticoagulants ), as prescribed by your doctor, and acquired independently.

Medroxyprogesterone: Dosage

Before use depo Medroxyprogesterone, please consider the following information.

In case of Dysfunctional (anovulatory) uterine bleeding Medroxyprogesterone is administered in a dose of 5-10 mg / day for 10 days. During this time the bleeding gradually stops. 3-7 days after discontinuation of the drug there might be bleeding. After this the treatment can be repeated, starting with the reception of Medroxyprogesterone at 16 day of cycle for 2-3 cycles.

To prevent the development of hyperplastic effects of the endometrium during estrogen therapy in menopause period, Medroxyprogesterone is prescribed 5-10 mg for at least 10 days starting from 16 day for a 25-day course of treatment with estrogens. On the 3-7 day after taking Medroxyprogesterone the patient should notice bleeding.

One can use Medroxyprogesterone, but it is recommended to consult your physician first.

In order to treat endometriosis Medroxyprogesterone is recommend to be given at a dose of 10 mg 3 times a day for 90 days starting on the 1 day of cycle.

For the differential diagnosis of primary and secondary amenorrhea use Medroxyprogesterone is administered in a dose of 5-10 mg per day for 10 days.

Medroxyprogesterone: Side effects

Before use Medroxyprogesterone, you should know that all drugs have certain side effects. When taking Medroxyprogesterone there might be noted:

Allergic reactions: urticaria, rash, cases of anaphylactoid reactions.

From the blood coagulation system: thromboembolism, thrombophlebitis.

CNS: nervousness, insomnia, drowsiness, weakness, depression (which may be similar to depression, often occurs before menstruation ), dizziness, headache.

Gastrointestinal: nausea.

On the part of the genitals: the changing nature of the genital tract secretions, breast tenderness and galactorrhea.

Other: weight changes, pyrogenic reactions.

In very rare cases, you may feel hungrier and more thirsty than usual, due to changes in the level of sugar in your blood. If any such manifestations inform your doctor immediately.

If these manifestations are not just the nature of lung trouble, pause pills and talk to your doctor. Also contact your doctor if you experience any bleeding that lasts more than two weeks.