Tinidazole is an antimicrobial agent, active against Trichomonas vaginalis, Entamoeba histolytica, Lamblia; pathogens anaerobic infections (Bacteroides spp., Including Bacteroides fragilis, Bacteroides melaninogenicus, Clostridium spp., Eubacter spp., Fusobacterium spp., Peptococcus spp., Peptostreptococcus spp.). As a highly lipophilic drug penetrates Trichomonas and anaerobic microorganisms, where restored by nitroreductase, inhibits the synthesis and damages the structure of DNA.
Before use Tinidazole, please consider the following information.
Trichomoniasis, giardiasis, amoebiasis (including hepatic form and amoebic dysentery), acute ulcerative gingivitis, nonspecific vaginitis, cutaneous leishmaniasis, infection with different localization caused by anaerobic bacteria: peritonitis, abscess, endometritis, piosalpinks, sepsis, wound infection (in including the prevention of postoperative anaerobic infections), infections of the skin and soft tissue, pneumonia, empyema, lung abscess, mixed aerobic- anaerobic infections (in combination with antibiotics); eradication of Helicobacter pylori (in combination with drugs and antibiotics Bi). One can use Tinidazole with no rx, but it is recommended to consult your physician first.
If you wonder how to use Tinidazole, you should also know its main contraindications before use Tinidazole.
Hypersensitivity, organic diseases of the central nervous system, suppression of bone marrow hematopoiesis, pregnancy (I trimester), lactation, children (under 12 years).
Tinidazole: Side effects
From the digestive system: loss of appetite, dry oral mucosa, ” metallic” taste in the mouth, nausea, vomiting, diarrhea. The nervous system: headache, dizziness, fatigue, impaired coordination of movements (including ataxia), dysarthria, peripheral neuropathy, rarely – seizures, weakness. Allergic reactions: urticaria, pruritus, skin rash, angioedema. Overdose. Treatment: symptomatic. No specific antidote. Displayed during dialysis.
If you ask yourself a question “generic Tinidazole”, you should contact the pharmacy.
Before use Tinidazole, you should know that the treatment with the medicine requires individual dosage. Must be taken during or immediately after a meal. Adults are prescribed 2 g once, for children – 50-75 mg / kg body weight (up to 2 g). With inefficiency (the presence of Giardia contents duodenum 10 or feces 19 days after the end of therapy), repeat the treatment at the same dose. Recommended treatment of all family members simultaneously. Urogenital trichomoniasis adults administered 2 g once. An alternative dosing regimen: 150 mg 3 times a day for 5 days or 150 mg two times a day for 7 days. In the treatment of vaginal trichomoniasis recommended additional local treatment. Children – 75 mg / kg body weight if necessary, may re-appointment at the same dose. Amebiasis liver: adult – 1.5-2 g / day in 1 reception for 3 days, if necessary, treatment should be continued with the same doses up to 5-6 days. Alternative: 600 mg 2 times a day for 5-10 days. Services – 50-60 mg / kg 1 time a day for 5 days. Acute ulcerative gingivitis – 2 g once. When nonspecific vaginitis – 2 g single dose, or in a series of 2 g for 2 days. Under anaerobic infections (Bacteroides, Fusobacterium, Clostridium spp.) Course of treatment – 5-6 days on the first day of treatment – 2 g / day, followed by 1 1 g once a day or 0.5 g, 2 times a day. To prevent postoperative anaerobic infections administered 2 g per 12 hours before the operation.
In the treatment of genital trichomoniasis should be simultaneous treatment of sexual partners. In the course of treatment should refrain from the use of ethanol. Tinidazole might cause dark staining of urine. In the appointment of more than 6 days is necessary to monitor patterns of peripheral blood. Safety and efficacy for the treatment and prevention of anaerobic infections in children under 12 years have not been established. During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and speed of psychomotor reactions.
Before use Tinidazole, you should know that it enhances the effect of indirect anticoagulants (to reduce the risk of bleeding, reduce the dose by 50%) and the effect of ethanol. Compatible with sulfonamides and antibiotics (aminoglycosides, erythromycin, rifampin, cephalosporins). Phenobarbital accelerates metabolism.